Massive macular subretinal hemorrhage caused by age-related macular degeneration
Conditions
Interventions
Vitrectomy combined with subretinal injection of alteplase group:Vitrectomy combined with subretinal injection of alteplase
Vitreous cavity injection of alteplase combined with pneumatic displacement surgery group:Vitreous cavity injection of alteplase combined with pneumatic displacement surgery
Sponsors
The First Affiliated Hospital of Xi'an Jiaotong University
Eligibility
Sex/Gender
All
Age
40 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Subretinal hemorrhage caused by AMD; 2. subretinal hemorrhage involving the macula and>2PD; 3. blood mainly located on the RPE, macular OCT thickness >= 250um; 4. subretinal hemorrhage <= 15 days; 5. age over 40 years old, and good compliance with study follow-up.
Exclusion criteria
Exclusion criteria: 1. Major macular subretinal hemorrhage caused by other reasons; 2. subretinal hemorrhage not involving the macula; 3. subretinal hemorrhage greater than 15 days; 4. patients with vitreous hemorrhage; 5. severe macular and optic nerve disease; 6. macular OCT thickness<250um.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Best corrected visual acuity; | — |
Secondary
| Measure | Time frame |
|---|---|
| Bleeding area;visual field;macular thickness;spontaneous fluorescence; | — |
Countries
China
Contacts
Public ContactYuhong Cheng
The First Affiliated Hospital of Xi'an Jiaotong University
Outcome results
None listed