None
Conditions
Interventions
Silver clip group (Experimental group):None
Sterilization group (control group):None
Tool contraceptive group (cntrol group):None
Sponsors
The Second Hospital of Hebei Medical University
Eligibility
Sex/Gender
Female
Age
40 Years to 70 Years
Inclusion criteria
Inclusion criteria: Inclusion Criteria for the Experimental Group: 1. Aged 40-70 years old, who have undergone silver clip sterilization in the past, and intend to undergo surgical treatment due to benign gynecological diseases (surgical resection includes bilateral fallopian tubes); 2. Long-term residence in the place of origin after sterilization; 3. Agree and be able to follow planned study visits, treatment protocols, laboratory tests, and other study procedures. Inclusion Criteria for the Control Group: Inclusion Criteria for Ligation Control Group: 1. Females who have undergone sterilization in the past; The age difference between the patients in the experimental group and the experimental group was less than 10; 2. Live in the same county as the patients in the experimental group; 3. The operation time was within 1 month after surgery for the patients in the experimental group. The remaining criteria were the same as those in the experimental group. Inclusion Criteria for the Instrumental Contraceptive Group: 1. Women who take contraception with tools; The remaining criteria were the same as those in the experimental group.
Exclusion criteria
Exclusion criteria: Exclusion criteria of the experimental group: 1. those who have undergone abdorminal procedure (include ceserean section with sterilization) 2. those who have previously undergone other metal implants (such as esophageal pacemaker implantation, heart valve replacement, fracture metal material fixing, metal sutures or clipsetc); 3. those whose workplaces are contaminated with heavy metals; 4. those who reside 20 km or less from a factory contaminated with heavy metals; 5. those who have a history of utilizing silver utensils, long-term use of silver jewelry, hair dye, or makeup; 6. those who currently have or had a serious pelvic and abdominal infection in the past ; 7. People who, in the researchers' opinion, are unsuitable for participation in this study. Exclusion criteria for the control group: the same as the exclusion criteria for the experimental group.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cytokines (tumor necrosis factor-a, interleukin 1-ß, interleukin 6, interleukin 8, interleukin 10);Coagulation function;Tissue factor, tissue factor pathway inhibitor; | — |
Secondary
| Measure | Time frame |
|---|---|
| Fallopian tube epithelial cells (number density, volume density, surface area density, and scanning electron spectroscopy of organelles);Pelvic Adhesion Score; | — |
Countries
China
Contacts
Public ContactLijuan Zhang
The Second Hospital of Hebei Medical University
Outcome results
None listed