Depression, anxiety, pain
Conditions
Interventions
Esketamine group:Intravenous esketamine at the appropriate dose
Control group:None
Thoracic paravertebral block combined with esketamine group:The patient underwent a thoracic paravertebral block after induction of anesthesia, in addition to the corresponding dose of esketamine.
Sponsors
The First Hospital Of Jiaxing
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.18 years old <= age <=75 years old, male or female; 2. Patients undergoing elective thoracoscopic radical resection of primary lung cancer under general anesthesia; 3.18kg/m2<=BMI<=32kg/m2; 4. American Society of Anesthesiologists (ASA) grade I-III; 5. Able to understand the use of pain scales, operate PCA equipment, and communicate effectively with researchers; 6. No contraindications to study drug use; 7. Clearly understand and voluntarily participate in the study, and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1.Severe cardiovascular system diseases, NYHA heart function grade 3~4; Heart block (sinus block or atrioventricular block); 2.Diseases of the kidney system (serum creatinine above the normal threshold); 3.Diseases of the liver system (Alt or Alt greater than twice the normal value); 4.Coagulation dysfunction (prothrombin time or activated partial thromboplastin time higher than the normal threshold); 5.Recently received antidepressant medication; 6.The drugs used in this study are contraindicated; 7.Alcohol abuse or heavy dependence on narcotic drugs in the last two months; 8.Recently received antidepressant medication; 9.Have severe mental or cognitive impairment; 10.Pregnant and lactating women; 11.With other primary cancer or malignancy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Anxiety score;Depressive score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Anxiety score;Intraoperative dosage of urapidil and ephedrine;Postoperative nausea, vomiting, dizziness, lethargy, pruritus, deep vein thrombosis, pulmonary embolism, atelectasis, intestinal obstruction, urinary retention, frequent urination and urgency;Postoperative pain score;The first time PCIA was used;Depressive score;Incidence of intraoperative hypertension, hypotension, bradycardia, dosage of urapidil and ephedrine.;Postoperative recovery quality;Sleep quality was assessed; | — |
Countries
China
Contacts
Public ContactTang Li
The First Hospital Of Jiaxing
Outcome results
None listed