postoperative pain
Conditions
Interventions
Experimental group:T4 and T6 thoracic paravertebral nerve block, bupivacaine liposomal 266mg + bupivacaine 60mg, 30 ml in total.
Control group:T4 and T6 thoracic paravertebral nerve block with 30 ml of 0.2% bupivacaine (60 mg of bupivacaine)
Sponsors
The Fourth Hospital of Hebei Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age>=18 years old, gender is not limited; 2. Thoracoscopic segmental/lobectomy under elective general anesthesia; 3. BMI 18~30 kg/m^2; 4. American Society of Anesthesiologists (ASA) grade I.-III 5. Understand the research process and the use of pain scales.
Exclusion criteria
Exclusion criteria: 1. Severe hepatic or renal insufficiency; 2. Hypersensitivity to liposomal bupivacaine or to the active ingredients or excipients of bupivacaine injection; 3. Patients with coagulation disorders; 4. History of analgesic dependence; 5. Patients with abnormal sensation in the innervated cortical area and peripheral neuropathy; 6. History of severe cardiovascular disease (congestive heart failure or unstable angina or myocardial infarction within 6 months); 7. Patients who are pregnant or breastfeeding 8. Patients who are unable to communicate effectively due to speech or hearing impairment, etc; 9. Refusing to participate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of moderate to severe pain within 72 hours after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Sleep quality in the first 2 days after surgery;TheAnalgesic medication consumed during the 3 postoperative days;;Time of first remedy;Frequency of remedies;Patient outcome questionnaire (IPOQ scale) scores on postoperative day 2;The incidence of postoperative adverse reactions;;Length of postoperative hospitalization;Major complications within 30 days postoperatively; | — |
Countries
China
Contacts
Public ContactHuiqun Jia
The Fourth Hospital of Hebei Medical University
Outcome results
None listed