Liver cancer
Conditions
Interventions
Propoful group :In group P, propofol 1.5-2.0mg/kg was intravenously injected for induction, and anesthesia was maintained by intravenous pumping of propofol 4-6mg/kg/h
Remimazolam group:In group R, remimazolam 0.2mg/kg was intravenously injected for induction and remimazolam 0.4-1.2mg/kg/h was intravenously pumped for anesthesia maintenance
Sponsors
Third Affiliated Hospital of Sun Yat sen University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. American Society of Anesthesiologists physical status I-III, aged 18-65 yr, BMI 18-28 kg/m2; 2. The functions of important organs were basically normal before surgery, without chemotherapy or radiotherapy, autoimmune system diseases, endocrine system and metabolic diseases; 3. No symptoms of pulmonary infection or fever before operation (no abnormal chest X-ray or chest CT report; Body temperature was normal; Blood routine WBC(4-10)×10^9/L); 4. Preoperative unconscious dysfunction; 5. Access to newspapers; 6. Agree to participate in this clinical trial and sign the informed consent form voluntarily.
Exclusion criteria
Exclusion criteria: 1. Those who are allergic to narcotic drugs, or use or abuse benzodiazepines and opioids for a long time; 2. Use of antidepressants, sedatives, analgesics or alcohol before surgery; 3. Participants who have participated in previous clinical trials related to remimazolam; 4. Patients with severe heart, lung, brain and other vital organ lesions, or severe liver and renal dysfunction (Child-Pugh grade C; Serum creatinine (Scr)=178µmol/L; Blood urea nitrogen (BUN) =9mmol/L); 5. Patients with preoperative psychiatric problems (such as chronic depression or severe bipolar disorder); 6. Patients who cannot communicate effectively with investigators or refuse to participate in the study; 7. Family members or patients declined to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of postoperative fatigue syndrome within 3 days after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Vital signs were monitored;Recovery quality monitoring; | — |
Countries
China
Contacts
Public ContactLiu Jun
The Third Affiliated Hospital of Sun Yat-sen University
Outcome results
None listed