vulvar lichen sclerosus
Conditions
Interventions
Case:No intervention
Control:No intervention
Sponsors
Peking Union Medical College Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1.Case: Adult women with typical clinical manifestations of VLS,including itching and depigmentation of the external genitalia; 2.Case: Pathological biopsy confirms VLS; 3.Control: Adult women without visible inflammation of the external genital skin; 4.Control: No skin lesions within 5mm around the specimen; 5.Control: Pathological confirmation shows normal skin on the external genitalia;
Exclusion criteria
Exclusion criteria: 1.Case: use of local steroids/immunomodulators within 1 week (including local glucocorticoids and calcineurin inhibitors); 2.Case: use of systemic immunosuppressants or phototherapy within 4 weeks; 3.Case: use of moisturizer within 12 hours; 4.Case: Vaginitis, invasive cancer, and carcinoma in situ; 5.Control group: Infectious diseases, malignant tumors, autoimmune diseases; 6.Control group: Hormones or immunosuppressants used within 2 months before sampling;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The cell clusters mainly involved in the pathological mechanism of VLS; | — |
Countries
China
Contacts
Public ContactZhijing Sun
Peking Union Medical College Hospital
Outcome results
None listed