Perioperative depression
Conditions
Interventions
Exposed group (Application of esmketamine):NA
Non-exposed group (Not using esmketamine):NA
Sponsors
Women’s Hospital of Nanjing Medical University, Nanjing Women and Children’s Healthcare Hospital
Eligibility
Sex/Gender
Female
Age
60 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. ASA grade I-II; 2. Aged 60-80 years old; 3. Body mass index = 35 kg/m^2; 4. Elective gynecological cancer surgery.
Exclusion criteria
Exclusion criteria: 1. Patients with severe cardiovascular disease, hyperthyroidism or risk of increased intracranial pressure; 2. Previous psychiatric diseases (such as Parkinson's disease, depression, anxiety, etc.); 3. History of psychotropic drug, opioid drug or alcohol dependence; 4. Contraindications to general anesthesia or patients refusing general anesthesia; 5. Patients with known ingredients of the study drug or allergy to other drugs used in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hospital Anxiety and Depression Scale (HADS);VAS pain scores; | — |
Secondary
| Measure | Time frame |
|---|---|
| 15-item quality of recovery scale (QoR15);Confusion Assessment Method for the Intensive Care Unit (CAM-ICU );NRS, AIS;Total intraoperative consumption of opioid sufentanil;Use of rescue analgesics;PONV;adverse events (Respiratory depression, dizziness and mental side effects);severe complications (Pulmonary complications, cardiac complications, central nervous system complications, gastrointestinal complications, sepsis, postoperative bleeding, reoperation, death);Postoperative hospitalization days; | — |
Countries
China
Contacts
Public ContactWen Yazhou
Women’s Hospital of Nanjing Medical University, Nanjing Women and Children’s Healthcare Hospital
Outcome results
None listed