Osteoarthritis
Conditions
Interventions
Platelet final concentration group (PLT< 1000×109/L, 1000~1500×109/L, 1500~2000×109/L, 2000~2500×109/L):One hundred and twenty patients with osteoarthritis of the knee were selected and divided into 4
Number of PRP injections (3 groups with less than 2 PRP injections, 3 injections, and 4 or more PRP injections):Ninety patients with osteoarthritis of the knee were selected and divided into three gro
Autoapheresis PRP preservation group (one group is the first use of autoapheresis PRP stored at 22-24 °C, the last two times stored at -80 °C, and the other group is PRP frozen at -80 °C for all three
Sponsors
The 960th Hospital of the PLA Joint Logistics Support Force
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. At least 18 years old, meeting the diagnostic criteria for osteoarthritis of the knee in the Osteoarthritis Diagnostic and Treatment Guidelines (2018 edition). 2. The Kellgren-Lawrecne classification based on X-ray changes is in grade I to III. 3. No anticoagulant drugs such as aspirin and rivaroxaban within 5d. 4. No related therapeutic drugs or treatment measures within 2 weeks. 5. Voluntarily participate in the clinical study and sign the Informed Consent Form.
Exclusion criteria
Exclusion criteria: 1.History of knee trauma and surgery; 2.Combined with rheumatism, rheumatoid arthritis 3.Have congenital deformity of lower limb or abnormal force line;. 4.Combined with haematopoietic system diseases; 5. Other patients who are not suitable for enrollment after evaluation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| VAS pain score,;WOMAC score ;Lysholm score; | — |
Countries
China
Contacts
Public ContactHuang Xiangyan
The 960th Hospital of the PLA Joint Logistics Support Force
Outcome results
None listed