Thrombocytopenia after umbilical cord blood transplantation
Conditions
Interventions
Sponsors
Children's Hospital of Soochow University
Eligibility
Sex/Gender
All
Age
No minimum to 18 Years
Inclusion criteria
Inclusion criteria: 1.Age<18 years old, both male and female; 2.Children with hematological disorders who have completed their first umbilical cord blood transplantation; 3.ECOG score <=2 points; 4.The subjects and their legal guardians agree to participate and sign an informed consent form;
Exclusion criteria
Exclusion criteria: 1.Patients who have not engrafted neutrophils within 14 days after transplantation; 2.Patients who develop severe acute GVHD (Graft-Versus-Host Disease) within 14 days after transplantation and have not been controlled; 3.Engraftment Syndrome (ES) that occurs within 14 days after transplantation and is not controlled; 4.Uncontrollable organ damage; 5.Patients with a history of venous/arterial thromboembolism and hereditary coagulation disorders; 6.Patients with abnormal liver and kidney function: alanine aminotransferase (ALT) and aspartate aminotransferase (AST) exceeded 3 times the upper limit of normal value, total bilirubin exceeded 3 times the upper limit of normal value, and blood creatinine exceeded 3 times the upper limit of normal value during screening; 7.Patients with QT interval prolongation on electrocardiogram; 8.Other conditions deemed unsuitable for inclusion in the study by the investigator;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The time of platelet implantation after transplantation; | — |
Secondary
| Measure | Time frame |
|---|---|
| The time for neutrophils to reach 1.0×109/L after transplantation;Serum ferritin levels;Cumulative incidence of graft-versus-host disease one year after transplantation;The proportion of graft-versus-host disease without recurrence at 1 year;The platelet count reached 50×109/L after transplantation;Incidence of delayed platelet implantation (DPE) (platelet count < 20×109/L 40 days after transplantation);Number of platelet transfusions;Medical expenses during hematopoietic reconstruction;Security; | — |
Countries
China
Contacts
Public ContactShaoyan Hu
Children's Hospital of Soochow University
Outcome results
None listed