None
Conditions
Interventions
Experimental Group:Remimazolam besylate
control group:Propofol
Sponsors
Huzhou Center Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Age >= 18 years old and <= 75 years old; 2.The estimated duration of mechanical ventilation = 48 hours; 3.The condition is allowed to be maintained in a state of shallow sedation (RASS -2~0); 4.Obtain informed consent from the patient or family;
Exclusion criteria
Exclusion criteria: 1.Pregnancy or breastfeeding; 2.Patients who require surgery under general anesthesia within 48 hours; 3.Severe, pre-existing parenchymal liver disease with clinically significant portal hypertension, Child-Pugh class C cirrhosis, or acute liver failure; 4.Patients with acute and chronic renal insufficiency requiring dialysis treatment; 5.Severe head injury, brain tumor, increased intracranial pressure, cerebrovascular accident, coma, status epilepticus, etc; 6.Patients with a history of alcohol or drug abuse; 7.Any condition that precludes proper assessment of cognitive function, such as speech and sensory impairment or psychiatric disorders (language difficulties or mental organic dysfunction); 8.Inability to obtain informed consent or authorization; 9.Participation in other exploratory clinical trials within 6 months prior to screening; 10.Known or suspected hypersensitivity to the study drug;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Duration of mechanical ventilation; | — |
Countries
China
Contacts
Public Contactxulan
Huzhou Center Hospital
Outcome results
None listed