Effect of different predictive methods in transthoracic echocardiography-guided fluid optimization on post-Induction hypotension during general anesthesia

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2500099892

Enrollment

Unknown

Registered

2025-03-31

Start date

2025-03-25

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

post-Induction hypotension during general anesthesia

Interventions

VTI steering committee:Volume optimization is mandated prior to anesthesia induction in patients with VTI-PLR >=10%

IVC steering committee:Volume optimization is mandated prior to anesthesia induction in patients with IVC-CI>=42%

Control Group:NO

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: 1. Elective surgery under general anesthesia with endotracheal intubation, 2. aged over 18 and 60 years, 3. 18 kg/m² <= BMI <= 30 kg/m², 4. Cardiovascular disease( NYHA class I–II), 5. ASA physicai status less than 3, 6. Signed informed , 7. Preoperative chest X-ray ,echocardiographic examination,ECG findings within normal limits.

Exclusion criteria

Exclusion criteria: 1. Pulmonary hyperinflation, such as in asthma, respiratory distress syndrome, or thoracic deformities, 2. Acute/chronic cardiac dysfunction, 3. Patients with valvular heart disease and myocardial hypertrophy, 4. Patients with ECG findings indicative of pronounced arrhythmia, premature beats, and other cardiac rhythm abnormalities, 5. Patients with spinal deformities, 6. Individuals with elevated intra-abdominal pressure (IAH), such as patients exhibiting peritoneal fluid accumulation (ascites), 7. Individuals with psychiatric disorders and comorbid cognitive dysfunction, 8. Patients with renal dysfunction/impairmen, 9. Patients with compromised postural compliance, 10. Patients with hydroxyethyl starch (HES) hypersensitivity.

Design outcomes

Primary

Measure	Time frame
Postinduction Hypotension;	—

Secondary

Measure	Time frame
General information of the patient (age, gender, BMI value, duration of drinking and fasting, ASA grading);The frequency and total amount of single intravenous infusion of epinephrine;The frequency and total amount of single intravenous injection of atropine;Does TTE assessment require capacity optimization? (Yes/No);Quickly supplement the total amount of hydroxyethyl starch 130/0.4 sodium chloride injection;Heart rate;Blood pressure (systolic, diastolic, mean arterial pressure);Monitoring value of anesthesia depth;Left ventricular outflow to diameter;Left ventricular outflow tract velocity time integral;stroke volume;cardiac output;	—

Measure

Time frame

General information of the patient (age, gender, BMI value, duration of drinking and fasting, ASA grading);The frequency and total amount of single intravenous infusion of epinephrine;The frequency and total amount of single intravenous injection of atropine;Does TTE assessment require capacity optimization? (Yes/No);Quickly supplement the total amount of hydroxyethyl starch 130/0.4 sodium chloride injection;Heart rate;Blood pressure (systolic, diastolic, mean arterial pressure);Monitoring value of anesthesia depth;Left ventricular outflow to diameter;Left ventricular outflow tract velocity time integral;stroke volume;cardiac output;

—

Countries

China

Contacts

Public ContactWuhua Ma

The First Affiliated Hospital of GuangZhou University of Chinese Medicine

tuesdaymorninggz@126.com+86 133 1886 0680

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026