Acute ischemic stroke
Conditions
Interventions
Study Group:None
Control Group:None
Sponsors
Xiyuan Hospital, China Academy of Chinese Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: Study Group Inclusion Criteria: 1. Meet the diagnostic criteria for acute cerebral infarction; 2. Onset time=13 points; 5. Be between the ages of 18-85; 6. Meet the indications for intravenous thrombolysis of alteplase within 4.5 hours, and receive intravenous thrombolysis therapy with alteplase; 7. Volunteer to take the test and sign the informed consent form. Inclusion Criteria for the Control Group: 1. Meet the diagnostic criteria for high-risk groups of stroke; 2. Match the gender, age and underlying cardiovascular and cerebrovascular diseases of the subjects in the study group; 3. Volunteer to be tested and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Severe circulatory, respiratory, urinary, digestive, immune, hematologic diseases, or cancer, or acid sphingomyelinase deficiency; 2. Subjects with a history of schizophrenia, intellectual retardation, or other diseases that limit participation in the validity of informed consent or investigation in this study; 3. Recent use of antibiotics, non-steroidal anti-inflammatory drugs, hormones, immunosuppressants and other anti-inflammatory drugs, or taking amitriptyline, trimipramine, desipramine, fluoxetine and other acid sphingomyelinase inhibitors; 4. Patients with language impairment who cannot cooperate with the investigation; 5. Inability to comply with the study protocol.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ceramide;Nucleotide-binding domain, leucine-rich repeat containing protein 3, NLRP3;Gasdermin D, GSDMD; | — |
Secondary
| Measure | Time frame |
|---|---|
| Interleukin-18, IL-18;Interleukin-1 beta, IL-1ß; | — |
Countries
China
Contacts
Public ContactYunling Zhang
Xiyuan Hospital, China Academy of Chinese Medical Sciences
Outcome results
None listed