Diabetes
Conditions
Interventions
Group A/Group B/Group C/Group D:None
Sponsors
Liaoning Provincial People's Hospital
Eligibility
Sex/Gender
All
Age
70 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Advanced age (> 70 years old); 2. Constipation (chronic constipation is defined as having less than three bowel movements per week, with or without the use of laxatives); 3. Diabetes mellitus (with comorbidities); 4. Obesity (BMI>=25Kg/m^2); 5. Patients and their families have given informed consent to the purpose and content of this study and voluntarily signed the informed consent form
Exclusion criteria
Exclusion criteria: 1. History of acute myocardial infarction (within 6 months), severe heart failure (New York class II-IV), chronic renal failure (stage 2-5) or mental disorder; 2. History of colorectal resection; 3. History of aspirin, warfarin or other anticoagulant drug use, or history of coagulation disorder; 4. History of taking any medications, proton pump inhibitors, non-steroidal anti-inflammatory drugs (NSAIDs) or antibiotics that may affect gastrointestinal motility (within the past 4 weeks), probiotics (within the last 2 weeks); Have taken linaclotide within 5.7 days or are known to be allergic to linaclotide; 6. Patients who are pregnant or breastfeeding during the study; 7. Patients with inflammatory bowel disease, frequent diarrhea, severe gastroparesis, intestinal perforation or intestinal obstruction; 8. Patients who cannot complete the whole course of colonoscopy; 9. Patients who have not provided written informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Adequate Bowel Preparation Rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Insertion time;Withdrawal time;Polyp Detection Rate ;Adenoma Detection Rate ;Adverse Reaction Rate;Compliance;Diminutive Polyp Detection Rate ; | — |
Countries
China
Contacts
Public ContactYao Yuan
Liaoning Provincial People's Hospital
Outcome results
None listed