quality of postoperative recovery
Conditions
Interventions
Group K1:Intraoperative intravenous pumping of esketamine 0.1mg/kg/h until 20min before the end of surgery
Group K2:Intraoperative intravenous pumping of esketamine 0.2mg/kg/h until 20min before the end of surgery
Group K3:Intraoperative intravenous pumping of esketamine 0.3mg/kg/h until 20min before the end of surgery
Group C:Intraoperative intravenous pumping of saline 10 ml/h until 20 min before the end of the operation
Sponsors
Affiliated Hospital of Xuzhou Medical University
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. patients undergoing knee arthroplasty under elective general anesthesia; 2. age 65 years or older; 3. ASA classification I-III; 4. BMI 18-28 kg/m^2; 5. receiving postoperative patient-controlled intravenous analgesia (PCIA)
Exclusion criteria
Exclusion criteria: 1. allergy to any drug used in the study; 2. glaucoma, elevated intracranial pressure, hyperthyroidism, or pheochromocytoma; 3. uncontrolled or poorly controlled hypertension, class III hypertension (very high risk), severe cardiac arrhythmia, severe cardiovascular disease (atherosclerosis, coronary artery disease, cardiac insufficiency, pulmonary artery disease, pulmonary hypertension); 4. severe hepatic or renal insufficiency ( Child-Pugh class C or need for renal replacement therapy); 5. recent use of any tricyclic antidepressant, sedative, opioid, monoamine oxidase inhibitor, or sleep-inducing medication within the past month; 6. refusal to provide informed consent or inability to cooperate with investigators.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative quality of recovery scores; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative quality of recovery scores;NRS pain score;AIS Sleep Score;Time from surgery to extubation;PACU Length of Stay;Perioperative use of sufentanil, remifentanil, and propofol;Incidence of intraoperative hypotension, hypertension, tachycardia, bradycardia, and arrhythmia;Intraoperative use of vasoactive drugs;Incidence of postoperative adverse effects (nausea and vomiting, pain, hemodynamic instability, respiratory depression, agitation, etc.);Duration of surgery;First postoperative bed activity and length of hospital stay;The number of effective postoperative compressions and the amount of additional analgesic medication used;Hemodynamic indices at special moments in the perioperative period; | — |
Countries
China
Contacts
Public ContactXiuxia Chen
Affiliated Hospital of Xuzhou Medical University
Outcome results
None listed