Holmium laser lithotripsy for ureteral stones
Conditions
Interventions
Test group:Anesthesia induction drugs: Within 10 minutes, administer a loading dose of 1 µ g/kg of dexmedetomidine by pump, and start anesthesia induction. Administer midazolam 0.03mg/kg, ketamine 0.5
Control group:Anesthesia inducing drugs: midazolam 0.03mg/kg, sufentanil 0.2-0.3 µ g/kg, rocuronium bromide 0.6mg/kg, propofol 2.0mg/kg.Continuous intravenous infusion of remifentanil 0.05-0.20 µ g/kg
Sponsors
Tianjin Fourth Central Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Participants who fully understood the purpose and significance of this trial, voluntarily agreed to participate, and signed the informed consent form. 2. Hospitalized patients diagnosed with ureteral stones scheduled for holmium laser ureterolithotripsy under general anesthesia with endotracheal intubation. 3. Age >=18 years, regardless of gender. 4. ASA physical status classification I-III.
Exclusion criteria
Exclusion criteria: 1. Refusal to sign informed consent; 2. Diagnosed psychiatric disorders with preoperative communication impairment due to cognitive or language barriers; 3. Uncontrolled or poorly controlled hypertension; 4. Significant risk of elevated blood pressure or intracranial hypertension; 5. Elevated intraocular pressure (glaucoma) or penetrating ocular trauma; 6. Untreated or inadequately treated hyperthyroidism; 7. Sick sinus syndrome with heart rate <50 beats per minute; 8. Severe cardiopulmonary, hepatic or renal comorbidities; 9. History of chronic pain with long-term or recent opioid abuse; 10. Pregnancy or lactation; 11. Known hypersensitivity to trial medications; 12. Participation in other drug trials or medical device studies within preceding 3 months;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative recovery quality; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative nausea and vomiting rate;Postoperative pain score;blood sugar; | — |
Countries
China
Contacts
Public ContactChunjing Zhou
Tianjin Fourth Central Hospital
Outcome results
None listed