People with arthritis of the knee or hip are more likely to suffer from sleep disorders
Conditions
Interventions
Esketamine group (E group):The subanesthetic dose of esketamine was administered intraoperatively, and the combined microdose of esketamine was administered postoperatively for
saline group (S group):Intraoperative infusion of the same dose of normal saline, postoperative use of conventional analgesic pump 48h
Sponsors
Peking University Shenzhen Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Age: 18-65 years old; 2. Total joint replacement surgery was performed with intraspinal anesthesia. 3. ASA Grade I - III; 4. The operation should be completed before 20:00 on the same day;
Exclusion criteria
Exclusion criteria: 1. Refuse to participate in the study; 2. BMI > 30kg/m^2; 3. Patients at high risk of sleep apnea syndrome before surgery (STOP-Bang score >=3 points); 4. a history of drug abuse; 5. severe cardiac insufficiency, severe liver and kidney insufficiency; 6. Patients with elevated blood pressure or cranial pressure, patients with intraocular hypertension or penetrating eye injury, patients with poorly controlled or untreated hypertension (resting systolic and/or diastolic blood pressure >=180 and/or \110mmHg); 7. Untreated or undertreated patients with hyperthyroidism; 8. Allergic or contraindicated to esketamine; 9. preoperative diagnosis of mental illness, cognitive dysfunction, or inability to communicate; 10. Unable to use the intravenous controlled analgesia pump; 11. Patients with contraindications to intraspinal anesthesia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Richards Campbell sleep questionnaire (RCSQ) score on the first night after surgery;; | — |
Secondary
| Measure | Time frame |
|---|---|
| Richards Campbell sleep questionnaire (RCSQ) score on the second night after surgery;;Total sleep duration on the first and second nights after surgery?Sleep efficiency((Sleep duration recorded by the bracelet/total sleep duration reported by the patient ×100););Sedation score 1-2 days after surgery (using Richmond agitation and sedation (RASS) score);NRS pain intensity was recorded during exercise and resting within 2 days after surgery (0: no pain; 1-3: mild pain; 4-6: moderate pain; 7-10: severe pain), twice daily (8-10am and 6-8pm) and postoper;Postoperative hospital stay (changed to postoperative hospital stay to the time interval between the date of operation and discharge);Anxiety and depression scores 1-2 days after surgery (using hospital Anxiety and Depression Scale HADS score);Pittsburgh Sleep Score (PSQI) 30 days after surgery; | — |
Countries
China
Contacts
Public ContactLi Yanze
Peking University Shenzhen Hospital
Outcome results
None listed