Major Depressive Disorder
Conditions
Interventions
Intervention group:Transcranial alternating current stimulation
Control group:Sham stimulation
Sponsors
Beijing Huilongguan Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged between 18 and 65 years, with an educational level of junior high school or above. 2. Meet the diagnostic criteria for a depressive episode according to the International Classification of Diseases, 10th Revision (ICD-10). 3. The discrepancy between subjective sleep duration and objective total sleep time is >=60 minutes, or the difference between subjective sleep efficiency and objective sleep efficiency is >=15%. 4. In the past two weeks, apart from taking escitalopram oxalate and zopiclone, no other sedative-hypnotic drugs, antidepressants, antipsychotic medications, or hormonal therapies have been used. 5. Patients voluntarily participate in the study, understand the content of the study, and sign an informed consent form.
Exclusion criteria
Exclusion criteria: 1. Severe physical illness with unstable health status (e.g., hypertensive patients whose blood pressure is not controlled within the normal range). 2. Concurrent intellectual disability or organic brain disease. 3. Substance use disorder. 4. Presence of other sleep-affecting disorders such as sleep apnea syndrome, central hypersomnia, parasomnia, or sleep-related movement disorders. 5. Received repetitive transcranial magnetic stimulation, electroconvulsive therapy without convulsions, transcranial electrical stimulation, or cognitive behavioral therapy within the past three months. 6. Presence of metal implants in the body, such as cardiac pacemakers or brain stimulators. 7. Allergy to electrode pad materials, specifically silicone. 8. Pregnant women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Subjective sleep;Anxiety symptoms;Depressive symptoms;Fatigue severity;Disease severity;Cognitive function;Objective sleep;Social function;Adverse effects of treatment;Inflammatory cytokines; | — |
Countries
China
Contacts
Public ContactShuangjiang Zhou
Beijing Huilongguan Hospital
Outcome results
None listed