Insomnia disorder
Conditions
Interventions
B group:Dexmedetomidine was injected with 0.05ug/kg/h pump at 21:00 on the night after surgery until 9:00 am the next day
C group:At 21:00 on the night after surgery, the same volume of normal saline was used to spray the nose in the same way
A group:1ug/kg dexmedetomidine hydrochloride nasal spray was used at 21:30 the night after surgery
Sponsors
The Third Affiliated Hospital of Guangzhou University of Chinese Medicine
Eligibility
Sex/Gender
All
Age
50 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Age 50-80 years old, gender is not limited; 2.ASA grade I to III, unilateral total knee replacement was selected, the anesthesia method was lumbo-epidural anesthesia; 3.PSQI score >=7, and meet the DSM-5 diagnostic criteria for insomnia disorder; 4.No patients with mental illness; 5.I or family members sign the study informed consent;
Exclusion criteria
Exclusion criteria: 1.Patients allergic to dexmedetomidine, patients with chronic sinusitis and other nasal diseases; 2.Respiratory history: history of severe chronic obstructive pulmonary disease, acute onset of chronic obstructive pulmonary disease, severe airway stenosis, throat mass, (branch) tracheoesophageal fistula, or airway tear, and severe respiratory infection within nearly 2 weeks prior to screening; 3.Cardiovascular history: uncontrolled hypertension [systolic blood pressure (SBP)>170mmHg and/or diastolic blood pressure (DBP)>105mmHg without antihypertensive drugs, Or SBP>160mmHg and/or DBP>100mmHg], aneurysm, severe arrhythmia, heart failure, Adams-stokes syndrome, New York Heart Association (NYHA) heart function grade >III, severe superior vena cava obstruction Syndrome, pericardial effusion, acute myocardial ischemia, unstable angina pectoris, myocardial infarction in the last 6 months prior to screening, history of tachycardia/bradycardia requiring medical treatment, degree II-III atrioventricular block (excluding pacemakers); 4.Liver, kidney, lung and other organ lesions serious; 5.Patients with central nervous system disorders, patients with sleep apnea syndrome and patients with other types of sleep disorders;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pittsburgh Sleep Quality Index;Polysomnography; | — |
Secondary
| Measure | Time frame |
|---|---|
| Psychomotor alertness test;Visual analog scale pain rating;Athens Insomnia Scale; | — |
Countries
China
Contacts
Public ContactHuang Ziqi
The Third Affiliated Hospital of Guangzhou University of Chinese Medicine
Outcome results
None listed