postoperative delirium
Conditions
Interventions
Active tACS Group:1. Receive real transcranial alternating current stimulation.
2. Parameters: 10 Hz frequency, 2 mA intensity, each lasting 30 minutes.
3. Stimulating electrodes were placed in the le
sham?tACS Group:1. Receive pseudo-stimulation for blinded control.2. There were only 30 s of current crescendo and decrescendo processes at the beginning and end of the stimulus.
3. No continuous 2 mA
Sponsors
Shanghai Jiaotong University Affiliated Sixth People ’s Hospital
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1 Age: >= 65 years old 2 American Society of Anesthesiologists (ASA) grade ?-? 3 Type of surgery: patients undergoing elective hip or knee replacement surgery
Exclusion criteria
Exclusion criteria: 1 Refusal to sign the consent form 2 Mini-Cog score <= 1 3 Nervous system diseases: such as Alzheimer's disease, Parkinson's disease 4 History of mental illness: patients with a previous history of serious mental illness (e.g., major depression, schizophrenia) 5 Severe hearing impairment 6 Taking central nervous system drugs: patients who are using sedatives, antidepressants, antipsychotic drugs, or other central nervous system drugs 7 Contraindications to transcranial electrical stimulation: such as implantable medical devices, history of epilepsy, severe scalp lesions or skin infections, intracranial tumors or other serious brain lesions 8 Acute infection or systemic inflammation: Acute infection or inflammatory state will increase the incidence of postoperative complications and may affect the independent assessment of delirium 9 Other study participation: patients who participated in other clinical trials within the last 3 months, so as not to confound the study results with multiple interventions
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| postoperative delirium (POD); | — |
Secondary
| Measure | Time frame |
|---|---|
| Duration of delirium;Severity of delirium;Subtypes of Delirium;Anxiety;Depression;Pain;Quality of sleep;Markers of inflammation;Cognitive function;Quality of postoperative recovery;Length of stay;Incidence of complications within 30 days after surgery;Adverse events;All-cause mortality; | — |
Countries
China
Contacts
Public ContactZhaojing
Shanghai Jiaotong University Affiliated Sixth People ’s Hospital
Outcome results
None listed