Effect of low dose esketamine pretreatment on cough, muscle fibrillation and postoperative recovery during anesthesia induction
Conditions
Interventions
Esketamine Group (Group A):0.3mg/kg Esketamine 10ml
Control group (Group B):Same 10ml normal saline pretreatment
Sponsors
Chinese People's Liberation Army Central Theater Command General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age >= 18 years old 2. Elective surgery with general anesthesia is planned 3. ASA grades I to II 4. Sign informed consent
Exclusion criteria
Exclusion criteria: 1. Patients allergic to ketamine, sufentanil, etomidate, or other related drugs 2. Pregnant or lactating women 3. Patients with severe cardiovascular, respiratory, liver and kidney dysfunction 4. Patients with a history of mental illness or substance abuse 5. Participants in other clinical trials in the past 3 months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cough and muscle fibrillation within 1 minute; | — |
Secondary
| Measure | Time frame |
|---|---|
| hemodynamics;Recovery time (time from the end of anesthesia to recovery);Postoperative pain;Brief Psychiatric Rating Scale;Quality of Recovery Scale; | — |
Countries
China
Contacts
Public ContactGuosheng Gan
Chinese People's Liberation Army Central Theater Command General Hospital
Outcome results
None listed