Clinical study of the effect of ambroxol irrigation of salivary glands on xerostomia in patients with primary Sjögren's

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2500099794

Enrollment

Unknown

Registered

2025-03-28

Start date

2025-04-01

Completion date

Unknown

Last updated

2025-03-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sjögren’s sydrome

Interventions

Control group:No salivary gland irrigation

Saline irrigation group:Saline irrigation of salivary glands

Aminophylline wash group:Ambroxol irrigation of salivary glands

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: To explore whether the irrigation treatment of ambroxol solution through the opening of salivary gland duct can improve the symptoms of xerostomia promote saliva secretion in patients with Sjögren's syndrome for a long time.

Exclusion criteria

Exclusion criteria: Exclusion of patients with hypertension, diabetes, acute salivary gland infection and previous radiotherapy of the head and neck; exclusion of subjects included in ambroxol group who had previously experienced an allergic reaction or other adverse reactions to the drug.

Design outcomes

Primary

Measure	Time frame
Un-stimulated whole saliva flow;stimulates whole saliva flow;citric acid-stimulated parotid flow;Clinical Oral Dryness Score;	—

Countries

China

Contacts

Public ContactFu Zhen

Nanjing Medical University Fourth Affiliated Hospital

fuzhen1982@njmu.edu.cn+86 181 6810 9123

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026