Postoperative cognitive dysfunction
Conditions
Interventions
Experimental group:30 minutes before surgery (preoperative preparation room), 60 minutes during surgery (after anesthesia induction), and 30 minutes after surgery (anesthesia resuscitation room) were
control group:30 minutes preoperatively (preoperative preparation room), 60 minutes intraoperatively (after anesthesia induction), and 30 minutes postoperatively (anesthesia resuscitation room) using
Sponsors
Huzhou Center Hospital
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Age >=65 years old; 2.American Society of Anesthesiology (ASA) Physical Conditions I-III; 3.Body Mass Index (BMI) 18~30 kg/m^2; 4.Hip or knee replacement surgery; 5.general anesthesia;
Exclusion criteria
Exclusion criteria: 1.Cognitive impairment determined by preoperative Mini Mental State Examination (MMSE) (less than 17 for illiterate individuals, less than 20 for those with primary school education or above, and less than 24 for those with high school education or above) or Montreal Cognitive Assessment (MoCA) [score<23 (one point can be added for<12 years of education)]; 2.Unable to communicate due to aphasia, severe hearing impairment, or other difficulties; 3.Use of psychotropic drugs (such as chlorpromazine, risperidone, olanzapine, haloperidol, and chlorpromazine); 4.Patients with a history of alcohol abuse or use of acetylcholine drugs; 5.During the study, sevoflurane, dexmedetomidine, scopolamine, and pentylethyl ether hydrochloride were used; 6.Severe circulatory system diseases (such as severe arrhythmia, hypertension, coronary artery disease, heart failure) and history of cardiac surgery; 7.Severe respiratory system diseases (respiratory failure, severe chronic obstructive pulmonary disease); 8.History of cerebral hemorrhage; 9.Coagulation abnormality; 10.Patients who refuse to use vagus nerve stimulation; 11.Patients with severe subcutaneous emphysema and serious adverse events (such as intraoperative bleeding and severe hemodynamic fluctuations); 12.Emergency operation; 13.Postoperative admission to ICU; 14.Decided to withdraw from the study during the research period; 15.Second surgery within 3 days after surgery;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Delayed neurocognitive recovery (DNR); | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative delirium;Postoperative Pain;Postoperative sleep quality;Postoperative anxiety score;Postoperative side effects; | — |
Countries
China
Contacts
Public ContactKeyu Fan
Huzhou Center Hospital
Outcome results
None listed