Severe drug-resistant bacterial infections in children
Conditions
Interventions
Ib group:Phage therapy combined with antibiotic treatment
Sponsors
Children's Hospital of Fudan University
Eligibility
Sex/Gender
All
Age
28 Days to 18 Years
Inclusion criteria
Inclusion criteria: 1. The patient is over 28 days old but under 18 years old; 2. Acute lower respiratory tract infection, with a pathogen infection cycle of less than 3 months; 3. The pathogenic bacteria causing pulmonary infection in patients should meet one of the following conditions: (1) The pathogenic bacteria are pan resistant bacteria (PDR); (2) Pathogenic bacteria are resistant to carbapenem resistant organisms (CRO); (3) Pathogenic bacteria are sensitive to key antibiotics outside the body, but this antibiotic treatment is clinically ineffective or ineffective (ineffective is defined as clinical efficacy is not significant, the condition does not improve or worsens, and microbiological treatment is ineffective (pathogenic bacteria cannot be cleared)); (4) Pathogenic bacteria have limited use of key sensitive antibiotics (such as organ toxicity or patients allergic to this antibiotic); 4. Capable of screening at least one lytic bacteriophage (virtual typing not required);
Exclusion criteria
Exclusion criteria: 1. Cannot be administered by nebulization inhalation; 2. Patients who have been determined by the researchers to be unsuitable for participation in this study;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Target bacterial clearance rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical outcome; | — |
Countries
China
Contacts
Public ContactGangfeng Yan
Children's Hospital of Fudan University
Outcome results
None listed