Postoperative pulmonary complications
Conditions
Interventions
N group:Aerosol inhalation of saline
KI group:Aerosol inhalation of esketamine
KV group:Intravenous pump infusion of esketamine
Sponsors
Nantong First People's Hispital
Eligibility
Sex/Gender
All
Age
60 Years to 84 Years
Inclusion criteria
Inclusion criteria: Patients who are to undergo laparoscopic radical colorectal cancer resection under general anesthesia were selected, aged 60 to 84 years old, ASA grade I~III., BMI 18.5-30kg/m^2, male or female.
Exclusion criteria
Exclusion criteria: 1. Patients with severe cardiovascular and cerebrovascular diseases; 2. Patients with severe liver and kidney dysfunction; 3. The preoperative pulmonary function test value is lower than 65% of the predicted value; 4. Long-term opioid users; 5. Patients with lung infection or systemic infection; 6. Those who have recently used anti-inflammatory drugs or antioxidant drugs; 7. Long-term use of glucocorticoids or immunosuppressants; 8. History of allergy to esketamine or contraindications to use, serious risk of elevated blood pressure and intracranial pressure, poorly controlled or untreated hypertension, untreated or undertreated hyperthyroidism, gastrointestinal bleeding.; 9. Have psychiatric illness and other chronic pain or other conditions that may confound analgesic responses; 10. Emergency surgery or trauma patients; 11. Previous abdominal surgery or intraoperative history.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of PPCs within 7days postoperatively; | — |
Secondary
| Measure | Time frame |
|---|---|
| OI=PaO2/FiO2;PA-aDO2;Respiratory Index(RI);Esketamine Plasma Concentration ;Cytokines (TNF-a; IL-1ß);Pain score;Time to get out of bed after surgery;Consumptions of the opioids drugs;Incidences of adverse reactions;Hhospital stays;Drainage tube remove time;Postoperative recovery of gasarointestin;The incidence of chronic postsurgical pain; | — |
Countries
China
Contacts
Public ContactLei Yao
Nantong First People's Hispital
Outcome results
None listed