Leiomyoma
Conditions
Interventions
Normal uterine smooth muscle cells control group:None
Metformin group (different concentration gradients):0, 1, 5, 10 mmol/L, concentrations optimized according to pre-experiments
Sponsors
The First Affiliated Hospital of Ningbo University
Eligibility
Sex/Gender
Female
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: (1) Diagnosis of uterine leiomyoma: Patients diagnosed with uterine leiomyoma through imaging examinations such as ultrasound and MRI. The diagnostic criteria include the size, location, and morphological characteristics of the fibroids, as well as the exclusion of other similar lesions (such as endometriosis) Symptoms, adenomyosis, etc (2) Physical health; (3) Clinical symptoms: There are obvious clinical symptoms, such as abnormal uterine bleeding, lower abdominal pain, compression symptoms, etc Some patients may experience anemia or other complications due to fibroids, requiring medication to alleviate symptoms; Patients who require surgical treatment; (4) Not pregnant or breastfeeding; (5) Exclude other diseases: Exclude other diseases that may cause similar symptoms, such as endometriosis, adenomyosis, etc Serious liver and kidney dysfunction, blood system diseases, infectious diseases, etc. were excluded; (6) Willing and able to participate with informed consent;
Exclusion criteria
Exclusion criteria: (1) Serious complications: Patients with severe anemia and anemia related complications (such as heart failure) Patients with severe liver and kidney dysfunction (2) Drug contraindications: For patients who are allergic to research drugs or allergic to drug ingredients Never used hypoglycemic drugs Previously used medication to treat uterine fibroids (3) Pregnant or lactating women: (4) Other situations: Patients with severe mental illness or inability to cooperate with the study Patients with suicidal tendencies or a history of mental illness
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proliferation index;AMPK expression level; | — |
Countries
China
Contacts
Public ContactGuan Yutao
The First Affiliated Hospital of Ningbo University
Outcome results
None listed