Intractable multiple warts of hands and feet caused by HPV infection
Conditions
Interventions
Experimental group:Thermotherapy combined with topical imiquimod cream.
Control group:Imiquimod cream for topical use only.
Sponsors
The FIrst Affiliated Hospital, College of Medicine, Zhejiang University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Patients aged 18-70 years old with multiple warts of hands and feet caused by HPV infection (number of warts >=5) who have received any treatment or combination treatment such as liquid nitrogen cryotherapy, laser therapy or local injection therapy for at least 3 times in the past, and whose rash still does not subside significantly or relapsed were treated with 5% imiquimote cream.
Exclusion criteria
Exclusion criteria: 1.Received local or systemic immunotherapy (including thermotherapy) or topical imiquimod cream within the past three months; 2.Physical therapy such as liquid nitrogen freezing within the past month; 3.Severely immunosuppressed patients (such as those with HIV infection, organ or bone marrow transplantation); 4.Patients with concurrent systemic use of immunosuppressants such as glucocorticoids.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total response rate of all groups at week 8; | — |
Secondary
| Measure | Time frame |
|---|---|
| The number and area of warts changed from baseline at week 8;Recurrence rate at week 24;Overall security for all groups at week 8; | — |
Countries
China
Contacts
Public ContactXiaoyan Liu
The FIrst Affiliated Hospital, College of Medicine, Zhejiang University
Outcome results
None listed