central precocious puberty
Conditions
Interventions
1 month dosage form Leuprolide group:None
ICPP untreated control group:none
3 month dosage form Leuprolide group:None
Sponsors
Huai'an First People's Hospital
Eligibility
Sex/Gender
Female
Age
6 Years to 11 Years
Inclusion criteria
Inclusion criteria: 1. Girls diagnosed with ICPP according to the diagnosis and treatment consensus of central precocious puberty, weighing 20-40 kg and aged 6-11 years; 2. Did not receive relevant drug treatment before seeking medical treatment; 3. The child has normal comprehension and expression skills; 4. Informed consent of children and their parents to the investigation plan.
Exclusion criteria
Exclusion criteria: 1. Secondary precocious puberty caused by diseases of the central nervous system, peripheral precocious puberty caused by genital tumors, endocrine system diseases, etc.; 2. Children with serious physical diseases, such as severe heart, liver, kidney, and hematopoietic diseases; 3. The child also suffers from other diseases that affect the quality of life, such as autism, intellectual disability, etc; 4. Children who cannot correctly understand the scale and fill in the form.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| pelvic ultrasound;Height, Weight, Tanner Stage;Serum sex hormones (FSH, LH, E2) levels; | — |
Secondary
| Measure | Time frame |
|---|---|
| Insulin-like growth factor 1;Blood triglycerides, cholesterol, blood sugar;Serum adipocytokines (leptin, adiponectin, chemokines);bone age; | — |
Countries
China
Contacts
Public ContactZhou wendi
Huai'an First People's Hospital
Outcome results
None listed