Cognitive impairment
Conditions
Interventions
experimental group:At night, there are 7 hours of wakefulness time, from 24:00 the previous day to 7:00 the next morning, and the working state is continuously awake
control group:Normal circadian rhythm for three consecutive days
Sponsors
Sanya Central Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Age >= 18 years old, regardless of gender, healthy adult; 2. The circadian rhythm is reversed (there are 7 hours of wakefulness at night, that is, from 24:00 the previous day to 7:00 am the next day, continuous wakefulness work state); 3. The total score of Pittsburgh sleep quality index (PSQI) is <= 5 points; 4. No smoking or alcohol addiction or other substance abuse, no habit of drinking tea, coffee and other beverages; 5. Understand the entire research content, voluntarily participate in the experiment and sign an informed consent form.
Exclusion criteria
Exclusion criteria: 1. Existence of any form of sleep disorders and mental illness related sleep disorders, such as insomnia, depression, anxiety disorders, schizophrenia, and other mental illnesses; 2. Existence of other neurological and psychiatric disorders; 3. The presence of any organic or functional diseases, such as digestive system diseases, cardiovascular and cerebrovascular diseases, endocrine and metabolic diseases, and other chronic inflammatory diseases; 4. Refusing to accept urine retention and venous blood collection; 5. Pregnant, lactating, or menstruating women;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| melatonin;Melatonin receptor;AQP4;LRP1;Aß40;Aß42;p-tau181;p-tau217;p-tau231;Trem2;AD7C-NTP; | — |
Countries
China
Contacts
Public ContactWang Gaiqing
Sanya Central Hospital
Outcome results
None listed