Acute ischemic stroke
Conditions
Interventions
Conventional standard treatment combined with air-bag type sequential external counter-pulsation group:Air-bag type sequential external counter-pulsation + conventional standard treatment (i.e., stand
Conventional standard treatment :Sham extracorporeal balloon counterpulsation + conventional standard of care
Sponsors
The Seventh Affiliated Hospital of Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. First non-cardiogenic ischemic stroke (meeting the diagnostic criteria of the 2018 Chinese Guidelines for the Diagnosis and Treatment of Ischemic Stroke), and the onset time is within 4 days to 3 weeks, male or female; 2.Between the ages of 18 and 80; 3.Obtaining informed consent.
Exclusion criteria
Exclusion criteria: 1.Significant cognitive, language, mental and behavioral abnormalities that cannot cooperate with testing and follow-up; 2.Participated in other clinical trials within 3 months; 3.Patients who have taken any autonomic nervous system medications such as catecholamine depleting agents, ß-blockers, a-blockers, antipsychotics, monoamine oxidase inhibitors, and tricyclic antidepressants within 14 days prior to enrollment; 4.Accompanied by neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, multiple sclerosis, mitochondrial encephalomyopathy, motor neuron disease, etc.); 5.Patients with severe organ dysfunction: alanine aminotransferase> 3 times the upper limit of normal; aspartate aminotransferase > 5 times the upper limit of normal; eGFR, 180 mm Hg or diastolic blood pressure >100 mm Hg); 10.Patients with epilepsy, pregnancy, metal or electronic implants in the body, obvious mental disorders, cognitive disorders, and claustrophobia that cannot cooperate with MRI examination.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cognitive function;Gait function; | — |
Secondary
| Measure | Time frame |
|---|---|
| Post-stroke autonomic dysfunction;Covert cerebrospinal fluid circulation disorders; | — |
Countries
China
Contacts
Public ContactQinghua Hou
The Seventh Affiliated Hospital of Sun Yat-sen University
Outcome results
None listed