delirium
Conditions
Interventions
Remimazolam group:Remimazolam anesthesia induction
propofol group:Propofol anesthesia induction
Sponsors
The Third Affiliated Hospital Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
18 Years to 55 Years
Inclusion criteria
Inclusion criteria: 1.Patients who meet the indications for MECT (Modified Electroconvulsive Therapy) treatment; 2.Patients who voluntarily participate and sign an informed consent form; 3.Age 18–55 years; 4. ASA classification of I–II; 5.Patients with mental disorders such as depression, schizophrenia, and bipolar disorder, who are receiving MECT treatment for the first time or have an interval of 6 months since their last MECT treatment. 6.Patients of Han ethnicity; 7.Right-handed patients; 8.Patients with at least a middle school education who can cooperate well with the relevant examinations; 9.Patients without contraindications for magnetic resonance imaging and who can cooperate well with functional MRI.
Exclusion criteria
Exclusion criteria: 1. Patients with a recent history of infections or severe trauma such as fractures; 2.Severe impairment of heart, lung, liver, or kidney function; 3.History of allergy to propofol or remimazolam; 4.Participation in any clinical drug trials within the past 3 months; 5.Lactating women or pregnant women; 6.Presence of organic brain lesions, such as cerebral aneurysm or increased intracranial pressure; 7.Lack of a legal guardian; 8.Patients with cognitive or intellectual disabilities; 9.Patients who cannot cooperate to complete scale assessments.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| post-ECT delirium,PECTD; | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in inflammatory markers;fMRI manifestations;Sedative Effects and Anesthesia Recovery;Seizure quality assessment;Cognitive function assessment;The status of clinical symptom relief;Hemodynamic changes and the incidence of adverse reactions.;Pre-treatment anxiety assessment;post-operative recovery quality;The patient's length of hospital stay and the total number of MECT sessions performed during the hospitalization.; | — |
Countries
China
Contacts
Public ContactHei Ziqing
The Third Affiliated Hospital Sun Yat-sen University
Outcome results
None listed