Recovery of consciousness in elderly patients undergoing spinal surgery
Conditions
Interventions
Intervention group:Remimazolam 0.025-0.1mg/kg was induced, 0.1-0.7 mg/kg/h was maintained , and 0.5mg (5ml) of flumaxinil was antagonized after drug withdrawal
Control group:Propofol 1-1.5mg/kg was induced, 4-10mg/kg/h was maintained, and the same amount of normal saline was given after drug withdrawal.
Sponsors
The Third Affiliated Hospital of Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age>=60 years; 2. Patients who intend to undergo spinal surgery under general anesthesia, including lumbar fusion surgery, cervical spine surgery, etc.; 3. ASA Class I-III; 4. Agree to participate in this study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Emergency surgery; 2. Inability to communicate verbally; 3. Preoperative insanity or dementia; 4. Other conditions, including intolerance or hypersensitivity to propofol or benzodiazepines, myasthenia gravis, schizophrenia, and severe depressive states; 5. Severe cardiac and pulmonary insufficiency.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The recovery time of consciousness in remazolam group and propofol group,; | — |
Secondary
| Measure | Time frame |
|---|---|
| Time of loss of consciousness after induction;Changes of MEP and SSEP amplitude in two groups of patients;Hypotension after anesthesia induction;Incidence of agitation during recovery;Incidence of re-sedation after awakening;Rate of PONV;Within 3 days after surgery;;Quality of recovery within 3 days after surgery; | — |
Countries
China
Contacts
Public ContactWeifeng Yao
The Third Affiliated Hospital of Sun Yat-sen University
Outcome results
None listed