chronic atrophic gastritis
Conditions
Interventions
Low-dose folic acid treatment group:Oral teprenone and low-dose folic acid
Control group:Oral teprenone and placebo
High-dose folic acid treatment group:Oral teprenone and high-dose folic acid
Sponsors
Beijing Friendship Hospital ,Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1.Ages between 18 and 70 years old; 2.Diagnosed with chronic atrophic gastritis by endoscopy and pathology; 3.Capable of regular follow-up; 4.Having signed an informed consent form;
Exclusion criteria
Exclusion criteria: 1.Patients with severe heart, liver, kidney, or other organ diseases; 2.Patients with malignant tumors; 3.Patients with inflammatory bowel diseases, intestinal obstruction, or other organic gastrointestinal diseases; 4.Patients with celiac disease, chronic pancreatitis, portal hypertension, or other digestive system diseases; 5.Patients with mental illnesses; 6.Patients who are pregnant, breastfeeding, possibly fertile without effective contraceptive measures, or planning to conceive; 7.Patients who are allergic to folic acid and/or teprenone;
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Long-term effectiveness of gastric mucosal inflammation and injury repair;Assessment of symptom improvement;Blood indicators of mucosal inflammation degree and activity;Pathological assessment of mucosal inflammation degree and activity;Safety examination;Compliance observation;Blood markers of mucosal inflammation severity and activity; | — |
Primary
| Measure | Time frame |
|---|---|
| The effectiveness of gastric mucosal injury repair; | — |
Countries
China
Contacts
Public ContactXiujing Sun
Beijing Friendship Hospital ,Capital Medical University
Outcome results
None listed