Acute ischemic stroke
Conditions
Interventions
Experimental group: Part I (Acute Phase Intervention) Part II (Post-discharge Intervention) Control group:Test group:
Part 1 (Acute Phase Intervention)
Conventional medical treatment, including anti
Control group:Conventional medical treatment alone with donepezil hydrochloride to control cognitive progression.
Sponsors
The Affiliated Hospital of Xuzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Subjects must meet all of the following criteria: General Inclusion Criteria: 1) Age 18-80 years old (including cut-off value) 2) Diagnosed with ischemic stroke (meeting the diagnostic criteria of the 2023 Chinese Guidelines for the Diagnosis and Treatment of Ischemic Stroke), and the onset time was within 48 hours. NIHSS score 3-25 (including cut-off value) 4) Subjects or family members sign the informed consent form
Exclusion criteria
Exclusion criteria: General Exclusion Criteria: 1) Hemorrhagic stroke; 2) Stroke onset with epilepsy and inaccurate NIHSS score for which an accurate NIHSS score cannot be obtained; 3) accompanied by coma or mental disorder, which may interfere with neurological assessment; 4) Patients with central nervous system diseases; 5) Those with cognitive dysfunction caused by other reasons; 6) Those who are intolerant to the treatment regimen involved in this study; 7) Pregnant or lactating people; 8) Poor compliance; 9) Severe hepatic and renal insufficiency, including but not limited to: liver cirrhosis, hepatic encephalopathy, ascites, renal failure or uremia (Ccr<25ml/min), hepatorenal syndrome, etc.; 10) Is participating in an interventional clinical trial and has used an investigational drug or medical device; 11) Subjects may not be able to complete this study for other reasons or those who should not be included in the opinion of the investigator;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Magnetically sensitive-weighted imaging SWI;MoCA score;MoCA score; | — |
Countries
China
Contacts
Public ContactCheng Yanbo
The Affiliated Hospital of Xuzhou Medical University, Xuzhou City, Jiangsu Province
Outcome results
None listed