children of HSPN with mild proteinuria
Conditions
Sponsors
children’hospital capital institute of pediatric
Eligibility
Sex/Gender
All
Age
6 Years to 18 Years
Inclusion criteria
Inclusion criteria: 1. Children of HSPN meet the following conditions? Age > 6 years old and = 8mg/h/M2 body surface area (or >= 300mg/d), and < 20mg/h/M2 body surface area (< 1000mg/d); 3. Sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Abnormal renal function: eGFR = IV; 3. Application of glucocorticoids and/or immunosuppressants within 2 weeks; 4. Hyperkalemia: serum potassium higher than normal value for the same age group; 5. Liver transaminase > 2 times the upper limit of normal; 6. Severe cardiac insufficiency; 7. Simultaneous use of CYPA4 inhibitors;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 24-hour urine protein quantification; | — |
Secondary
| Measure | Time frame |
|---|---|
| edema;rash;weight;blood pressure;respiratory symptom;digestive symptom;urine routine;Complete blood count;blood biochemistry;blood coagulation;Arterial blood gas analysis;urine microalbumin-to-creatinine ratio;urine protein-to-creatinine ratio;urine a1microglobulin-to-creatinine ratio;blood level of renin angiotensin aldosterone; | — |
Countries
China
Contacts
Public Contacttujuan
children’hospital capital institute of pediatric
Outcome results
None listed