Postpartum depression
Conditions
Interventions
Experimental group:Esketamine is given during the procedure and for the first two days after surgery. After the fetus is delivered, esketamine 0.2mg/kg diluted is given and pumped, pumped at a constan
Control group:Normal saline was used, infusion at the same rate, and the postoperative analgesic pump was sufentanil 100 µg tropisetron 10 mg prepared into 100 ml, background dose 2 ml/h, a single add
Sponsors
Maternal and Child Health Hospital of Jiangxi Province
Eligibility
Sex/Gender
Female
Age
18 Years to 35 Years
Inclusion criteria
Inclusion criteria: 1. Age>=18 years and less than 35 years; 2. Gestational age >=37 and less than 40 weeks; 3. ASA Class I-III; 4. Failure of transvaginal trial of labor; 5. Undergoing cesarean section under pseudo-neuraxial anesthesia; 6. Fasting for 6 hours and drinking for more than 2 hours before surgery; 7. No contraindications to neuraxial anesthesia (puncture site infection, coagulation dysfunction, etc.); 8. Plan to receive postoperative intravenous self-controlled analgesia.
Exclusion criteria
Exclusion criteria: 1. Refusal to participate in this study; 2. Preoperative epilepsy, Parkinson's disease, myasthenia gravis, intracranial hypertension, delirium, schizophrenia or other psychiatric diseases; 3. Inability to communicate due to coma, severe dementia or language impairment before surgery; 4. Severe uncontrolled hypertension before surgery (basal blood pressure SBP>180 mmHg or DBP>110 mmHg in the ward); 5. History of hyperthyroidism and pheochromocytoma before surgery; 6. Patients with severe abnormal liver function (Child-Pugh grade C), severe renal function abnormalities (receiving dialysis before surgery) or expected to survive for = 24 hours; 7. Acute cardiovascular events within 30 days prior to surgery; 8. Planning for organ transplantation, vascular surgery, neurosurgery, etc.; 9. Have been treated with ketamine or esketamine; 10. Those who are allergic to ketamine or esketamine or have contraindications to use; 11. Other situations that the investigator or the doctor in charge deem inappropriate to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of postpartum depression; | — |
Secondary
| Measure | Time frame |
|---|---|
| Edinburgh Postnatal Depression Score;Numeric rating scale scores;Neuropsychiatric symptoms (e.g., nystagmus, dizziness, headaches, nightmares and hallucinations);Nausea and vomiting;Recovery of postoperative gastrointestinal function (time to first gas and bowel movement);Preoperative and 3d postoperative maternal CRP, IL6, IL8, TNF-a values; | — |
Countries
China
Contacts
Public ContactLi Huanhuan
Jiangxi Maternal and Child Health Hospital
Outcome results
None listed