Carpal tunnel syndrome
Conditions
Interventions
GroupA:Nighttime splinting for 6 weeks
GroupC:Nighttime splinting for 6 weeks,combined with intracarpal tunnel injection of corticosteroids
Sponsors
Shanghai Sixth People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1)Patients are 18 years of age or older and have idiopathic carpal tunnel syndrome diagnosed by a specialist physician according to the Katz diagnostic criteria on the target side of the wrist; 2)The current episode has occurred within 6 weeks of enrollment assessment, and the target side of the joint has moderate-to-severe CTS symptoms and has not been treated.
Exclusion criteria
Exclusion criteria: 1) Patients who are scheduled to undergo surgical treatment for CTS within the next 6 months; 2) Any form of CTS that is part of another disease, including rheumatoid arthritis, psoriatic arthritis, systemic lupus erythematosus, CPPD (calcium pyrophosphate dihydrate deposition disease), etc.; 3) History of fracture or surgery on the target side of the joint; 4) Bilateral CTS with moderate or severe symptoms in both hands; 5) Received corticosteroid injections in the wrist within the past 6 months; 6) Patients who are unable to wear a splint due to trauma or other reasons; 7) Patients with clinical manifestations or electrophysiological changes indicative of significant axonal loss or denervation, including thenar muscle atrophy, sensory loss (two-point discrimination greater than 8 mm), absence of SNAP (sensory nerve action potential), absence of CMAP (compound muscle action potential) in the thenar muscles, etc.; 8) Patients who require long-term use of any form of analgesic medication, such as NSAIDs (nonsteroidal anti-inflammatory drugs), opioids, acetaminophen, etc.; 9) Patients who have used NSAIDs, opioids (e.g., tramadol), neuropathic pain medications (gabapentin, pregabalin, etc.), or oral corticosteroids within the past 2 weeks; 10) Patients who have received non-recommended wrist injection treatments (e.g., 5% glucose, platelet-rich plasma, ozone, chitosan, hyaluronic acid, etc.) within the past 6 months; 11) Patients who have undergone non-recommended physical therapies (e.g., electrotherapy, magnetotherapy, laser therapy, etc.) within the past 6 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Surgical rate within 52 weeks; | — |
Secondary
| Measure | Time frame |
|---|---|
| The change in the score of the Boston Carpal Tunnel Questionnaire Symptom Severity subscale (BCTQ symptom severity subscale) from baseline at 52 weeks.;The change in the score of the Boston Carpal Tunnel Questionnaire Symptom Severity subscale (BCTQ symptom severity subscale) from baseline at 6, 12, and 24 weeks.;The change in the score of the Boston Carpal Tunnel Questionnaire Function Status subscale(BCTQ function status subscale)from baseline at 6,12,24,and 52 weeks.;The change in EQ-VAS from baseline at 6, 12, 24, and 52 weeks.;The change in the Pittsburgh Sleep Quality Index(PSQI)from baseline at 6,12,24,and 52 weeks.; | — |
Countries
China
Contacts
Public ContactYun Qian
Shanghai Sixth People's Hospital
Outcome results
None listed