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Determining the duration of topical anesthetic drugs’ use for effective analgesia before various needle puncture procedures

The duration of topical anesthetic drugs’ use for effective analgesia before various needle puncture procedures

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500099576
Enrollment
Unknown
Registered
2025-03-26
Start date
2025-03-28
Completion date
Unknown
Last updated
2025-03-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

puncture pain

Interventions

EMLA-Venipuncture Group:The ET50 and ET95 of EMLA cream in suppressing venipuncture pain were determined by sequential methods with an initial time of 60 min for EMLA and an adjacent time gradient usi
if the NRS score was greater than 0, the next patients time was increased by a factor of 1.1, and so on. A line graph of the time to EMLA use can be obtained, with the first patient before the change
EMLA-arterial puncture group:The ET50 and ET95 of EMLA cream in suppressing arterial puncture pain were determined by sequential methods with an initial time of 60 min for EMLA and an adjacent time gr
EMLA-port non-coring needle puncture group:The ET50 and ET95 of EMLA cream in suppressing non-coring needle puncture pain were determined by sequential methods with an initial time of 60 min for EMLA
if the NRS score was greater than 0, the next patients time was increased by a factor of 1.1, and so on. A line graph of the time to EMLA use can be obtained, w

Sponsors

Shanghai Changzheng Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 120 Years

Inclusion criteria

Inclusion criteria: 1. During the study period, those who plan to undergo non-injury needle puncture at the infusion port or those who intend to undergo arterial puncture for elective surgery or those who plan to undergo venipuncture for elective surgery in our center; 2. Age 18 or above at the time of signing the informed consent;

Exclusion criteria

Exclusion criteria: 1. Those who are allergic to local anesthetics; 2. Those who are using drugs that may affect the metabolism of local anesthetics; 3. Those with contraindications to local anesthetics; 4. Long-term use of analgesic drugs; 5. Patients with neuropsychiatric diseases (aphasia, epilepsy, etc.).

Design outcomes

Primary

MeasureTime frame
Time of cream/gel use;

Secondary

MeasureTime frame
Sex;Age;Height;Weight;pain level;

Countries

China

Contacts

Public ContactJiang Guowei

Shanghai Changzheng Hospital

drgwjiang@126.com+86 180 1625 2892

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026