Coronary heart disease, chronic obstructive pulmonary disease, femoral head necrosis, femoral neck fracture
Conditions
Interventions
ciprofol group(B group):Administer cyclosporine injection at a dose of 0.3mg/kg.
Propofol group(A group):Administer propofol injection at a dose of 2mg/kg.
Sponsors
The First Hospital of Jiaxing
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patients =65 years old (male or female); 2. The American Society of Anesthesiologists(ASA)grades are ?-?; 3. Patients undergoing major orthopaedic surgery with faltering index (mFI) =0.27;
Exclusion criteria
Exclusion criteria: 1. Known allergy to eggs, soy products or experimental drugs (propofol, cyclopofol), opioids, etc.; 2. Patients with multiple injuries combined with other operations; 3. History of long-term use of psychotropic drugs, cognitive dysfunction, active psychiatric disease; 4. Severe cardiovascular system disease, severe respiratory disease; 5. History of substance abuse, drug use, alcohol abuse; 6. Refused to sign the informed consent. 7. Preoperative measurement of hemodynamic instability in patients using ICON measuring instrument;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cardiac output;mean arterial pressure; | — |
Secondary
| Measure | Time frame |
|---|---|
| Wake up extubation time;Usage of vasoactive drugs;postoperative complication;hospital stay; | — |
Countries
China
Contacts
Public ContactShen Xu
The First Hospital of Jiaxing
Outcome results
None listed