postoperative recovery quality
Conditions
Interventions
Control group: C1 group:Conventional propofol total intravenous anesthesia
Experimental group: K1 group:esKetamine intravenous assisted propofol total intravenous anesthesia
Control group:C2 group:Conventional sevoflurane inhalation anesthesia
Experimental group: K2 group:esKetamine assisted sevoflurane inhalation anesthesia
Control group:C3 group:Conventional combined anesthesia of intravenous and inhalation
Experimental group: K3 group:esKetamine intravenous assisted combined anesthesia of intravenous and inhalation
Sponsors
Xuzhou Central Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: Inclusion Criteria: 1.Age between 18-85 years; 2.Elective short-duration laparoscopic surgery with a surgical duration <=2 hours; 3.ASA classification I-III; 4.No communication barriers, clear consciousness; 5.BMI ranging from 18.5-28 kg/m²; 6.Willing to use postoperative intravenous analgesia devices; 7.Ethical compliance, voluntary participation, and signed informed consent.
Exclusion criteria
Exclusion criteria: Exclusion Criteria: 1.Presence of contraindications or allergies to esketamine or other anesthetic drugs; 2.Known or suspected abuse or long-term use of narcotic sedatives or analgesics; 3.Severe hypertension or severe cardiovascular disease; 4.Any cerebrovascular accident within the past 3 months; 5.Pulmonary hypertension, or excessively high intracranial or intraocular pressure; 6.History of mental illness, central nervous system injury, or cognitive dysfunction; 7.Severe hepatic or renal insufficiency; 8.History of use of antidepressants or other psychiatric medications.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Recovery quality within 24 hours after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Recovery quality within 48 hours after surgery; Recovery quality within 72 hours after surgery;Quality evaluation of anesthesia recovery in PACU;Changes in EEG of perioperative patients;Monitoring of blood concentration of esketamine;Expression of perioperative inflammation and anti inflammatory marker levels Expression of perioperative inflammation and anti-inflammatory markers levels;postoperative side reactions; | — |
Countries
China
Contacts
Public ContactLiwei Wang
Xuzhou Central Hospital
Outcome results
None listed