Opioid-free Anesthesia on Overall Benefit of Analgesia in Laparoscopic Cholecystectomy: A Multicenter, Randomized, Controlled Trial

Conditions

Analgesia in laparoscopic cholecystectomy

Zhao HX, Han L, Wang D, Jin J, Ji FH, Guo W, Liu H, Sudhan N, Li Y, Peng K.

2025-11-182 citations

10.1080/07853890.2025.2589570

Impact of opioid-free anesthesia on the overall benefit of analgesia score after laparoscopic cholecystectomy: protocol and statistical analysis plan for a multicenter, randomized, controlled trial

Zhao, Han-xue, Han, Liu, Wang, Dan, Jin, Jiayu, Ji, Fu-hai et al. (10 authors)

OPAL (Open@LaTrobe) (La Trobe University)2025-01-01

10.6084/m9.figshare.30655383.v1

Impact of opioid-free anesthesia on the overall benefit of analgesia score after laparoscopic cholecystectomy: protocol and statistical analysis plan for a multicenter, randomized, controlled trial

Zhao, Han-xue, Han, Liu, Wang, Dan, Jin, Jiayu, Ji, Fu-hai et al. (10 authors)

2025-01-01

10.6084/m9.figshare.30655383

Interventions

Opioid-based group:Anesthesia with sufentanil and sevoflurane

Opioid-free group:Anesthesia with esketamine, dexmedetomidine and sevoflurane

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: Aged 18-75 years, ASA I-III, scheduled for elective LC surgery, and signed informed consent.

Exclusion criteria

Exclusion criteria: Severe bradycardia (HR < 50 beats/min), sick sinus syndrome, or second-degree or higher atrioventricular block without pacemaker implantation; psychiatric disorders; inability to understand assessment scales; allergy to the medications used.

Design outcomes

Primary

Measure	Time frame
Overall Benefit of Analgesia Score (OBAS);	—

Secondary

Measure	Time frame
Pain on movement;Incidence of chronic pain;	—

Countries

China

Contacts

Public ContactPeng Ke

Department of Anesthesiology, The First Affiliated Hospital of Soochow University

pengke@suda.edu.cn+86 159 6215 5989

Outcome results

None listed