Tuberculosis
Conditions
Interventions
Tuberculosis patient Group:None
Mycobacterium tuberculosis latent infection group:None
Sponsors
Suzhou Fifth People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: The population included in this study can be divided into the following three categories: 1. Pulmonary tuberculosis patients: according to WS299-2017 "Diagnosis of Tuberculosis", 1) aged 18-65 years old; 2) patients with definite diagnosis of pulmonary tuberculosis or clinical diagnosis of pulmonary tuberculosis in our hospital; 2. Latent infection of Mycobacterium tuberculosis: according to WS196-2017 classification of tuberculosis, 1)aged 18-65 years old; 2) Ifn-? release test was positive; 3) no imaging signs of active or old tuberculosis; 4) no clinical symptoms of active tuberculosis such as fever, cough, night sweats and weight loss; 5) no previous history of tuberculosis. 3. Healthy people: 1) age >=18 years old; 2) Interferon-? release assay was negative; 3) no imaging signs of active or old tuberculosis; 4) no clinical symptoms of active tuberculosis such as fever, cough, night sweats and weight loss; 5) no previous history of tuberculosis; 6)denying the history of tuberculosis exposure.
Exclusion criteria
Exclusion criteria: Patients who met any of the following criteria were excluded: 1.pregnant or lactating patients; 2. patients with hematological malignancies; 3. people living with HIV; 4.suffering from autoimmune diseases; 5. immunosuppressive therapy; 6. after organ transplantation or hematopoietic stem cell transplantation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Single-cell multiplexed secretome proteomics; | — |
Secondary
| Measure | Time frame |
|---|---|
| Expression of serum cytokines; | — |
Countries
China
Contacts
Public ContactPing Xu
Suzhou Fifth People's Hospital
Outcome results
None listed