Multiple System Atrophy-cerebellar type
Conditions
Interventions
real group:Transcranial Magnetic Stimulation
Sham stimulation group:Sham stimulation using a dummy coil
Sponsors
Xuanwu Hospital Capital Medical University
Eligibility
Sex/Gender
All
Age
45 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Patients with Multiple System Atrophy - Cerebellar type (MSA-C) who meet the diagnostic criteria for clinical diagnosis or probable MSA-C according to the Chinese Expert Consensus on the Diagnosis of Multiple System Atrophy (2022); 2. No other neurodegenerative diseases; 3. Aged between 45 and 75 years, with no gender restrictions; 4. Willing to participate in the study and provide written informed consent; 5. Able to fully comply with the treatment and complete a 2-month follow-up.
Exclusion criteria
Exclusion criteria: 1. Patients with severe internal medical conditions, psychiatric disorders, or those without legal capacity or with restricted legal capacity; 2. Patients with significant abnormalities found in relevant tests and examinations (such as biochemical blood tests or abnormal electrocardiograms); 3. Patients with metal foreign bodies in the skull, cardiac pacemakers, cardiac stents, or cochlear implants; 4. Patients with intracranial infections, acute cerebral hemorrhage, or significantly elevated intracranial pressure; 5. Patients with a history of epilepsy or a family history of epilepsy, or those currently using bupropion or other medications that may increase the risk of TMS-induced seizures; 6. Patients with severe hearing or visual impairments that prevent cooperation with examinations; 7. Patients with pacemakers, aneurysm clips, artificial heart valves, cochlear implants, metal fragments, or foreign bodies in the eyes, skin, or body that are contraindications for MRI scanning.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the ScalefortheAssessment and Rating of Ataxia (SARA); | — |
Secondary
| Measure | Time frame |
|---|---|
| UMSARS,SARA,Berg balance scale;brain network; | — |
Countries
China
Contacts
Public ContactHua Lin
Xuanwu Hospital Capital Medical University
Outcome results
None listed