Postoperative analgesia after esophagectomy
Conditions
Interventions
Control group:Preoperatively, in the lateral decubitus position, ultrasound-guided ESPB using 40 ml of normal saline
Ropivacaine ESPB group:Preoperatively, in the lateral decubitus position, ultrasound-guided ESPB using 150 mg of ropivacaine diluted with normal saline to 40 ml
Bupivacaine liposomal ESPB group:Preoperatively, in the lateral decubitus position, ultrasound-guided ESPB using 266 mg of liposomal bupivacaine diluted with normal saline to 40 ml
Sponsors
The First Affiliated Hospital of Soochow University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Aged >=18 years; ASA classification I-III; scheduled for elective transthoracic esophagectomy (open thoracotomy or thoracoscopic/artificial pneumothorax combined with laparoscopic or open abdominal surgery); signed informed consent form.
Exclusion criteria
Exclusion criteria: Severe cardiopulmonary disease or hepatic/renal dysfunction; allergy to the medications used or a history of adverse reactions related to local anesthesia; history of chronic pain, neuropathic pain, or long-term use of analgesics before surgery; psychiatric disorders; inability to comprehend the scales used in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| mean OBAS within 1-5 days after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Cumulative opioid consumption;Major complications during hospitalization;5-year overall survival rate after surgery;Postoperative length of hospital stay;OBAS at each day during 5 days postoperatively; | — |
Countries
China
Contacts
Public ContactPeng Ke
Department of Anesthesiology, The First Affiliated Hospital of Soochow University
Outcome results
None listed