None
Conditions
Interventions
Ropivacaine combined with 0mg/ml esketamine group:Epidural analgesia
Ropivacaine combined with 0.25mg/ml esketamine group:Epidural analgesia
Ropivacaine combined with 0.50mg/ml esketamine group:Epidural analgesia
Ropivacaine combined with 0.75mg/ml esketamine group:Epidural analgesia
Sponsors
The Second Affiliated Hospital of Wenzhou Medical University
Eligibility
Sex/Gender
Female
Age
18 Years to 35 Years
Inclusion criteria
Inclusion criteria: (1) Full term pregnancy (37-42 weeks) (2) single primipara (3) ASA grade I-II (4) Age 18-35 years old (5) The woman requires epidural labor analgesia
Exclusion criteria
Exclusion criteria: (1) The patient refused esketamine (2) Those who are known to be allergic to lidocaine, ropivacaine and other local anesthetic drugs or other drugs in this test (3) There is abnormal platelet or clotting function, liver function or kidney function (4) People with previous cardiovascular, respiratory, nervous or psychiatric diseases (5) Skin and soft tissue infection at the puncture site, or trauma, fracture, surgical history, or lumbar disc herniation at the puncture site (6) There are factors such as head basin imbalance, giant baby, twin pregnancy (7) Participants considered unsuitable for clinical trials
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Effective analgesia rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Sensory block condition;Motor block condition;Hypotension;Bradycardia;Nausea and vomiting;Respiratory depression;Oversedation;Maternal pyrexia; | — |
Countries
China
Contacts
Public ContactZheng Shengxing
The Second Affiliated Hospital of Wenzhou Medical University
Outcome results
None listed