Anxiety disorder of childhood
Conditions
Interventions
Control group:None
Sponsors
First Affiliated Hospital of Kunming Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Anesthesia group 1. Children who have received 3 or more times of general anesthesia for elective surgery before the age of 3 years; 2. ASA Grading I.-III; 3. No history of intestinal diseases; 4. Gestational age at birth of 36 weeks or more. Control group 1. Children matched to age and sex in the anesthesia group; 2. No anesthetic exposure; 3. ASA Grading I.-III; 4. No history of intestinal diseases; 5. Gestational age at birth of 36 weeks or more.
Exclusion criteria
Exclusion criteria: 1.Preterm infants with gestational age < 36 weeks; 2.History of birth asphyxia; 3.Maternal exposure to general anesthesia during pregnancy; 4.Pre-existing developmental, cognitive, or behavioral disorders identified during pre-anesthesia screening; 5.Known conditions with potential impacts on neurodevelopment (e.g., genetic syndromes, epilepsy); 6.Children undergoing emergency surgeries; 7.Intraoperative adverse events (e.g., hypoxia, hemodynamic instability); 8.History of gastrointestinal surgery, inflammatory bowel disease, or functional dyspepsia; 9.Antibiotic use within 2 weeks prior to stool sample collection; 10.Parental or guardian refusal to participate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The alpha diversity index of intestinal flora (Shannon index);The alpha diversity index of intestinal flora (Simpson index);The alpha diversity index of intestinal flora (ACE index);The alpha diversity index of intestinal flora (Chao1 index);The relative abundance of intestinal flora at phylum level (Firmicutes);The relative abundance of intestinal flora at phylum level (Bacteroidetes);The relative abundance of intestinal flora at phylum level (Actinobacteria);The relative abundance of intestinal flora at phylum level (Proteobacteria);Scores from the Chinese version of the parent-reported Spence Children's Anxiety Scale (SCAS-P); | — |
Countries
China
Contacts
Public ContactYang Kun
First Affiliated Hospital of Kunming Medical University
Outcome results
None listed