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Effects of low dose esketamine on sleep quality, postoperative analgesia and inflammatory factors

Effects of low dose esketamine on sleep quality, postoperative analgesia and inflammatory factors

Status
Recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500099435
Enrollment
Unknown
Registered
2025-03-24
Start date
2024-06-05
Completion date
Unknown
Last updated
2025-03-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sleep quality

Interventions

Test group:A small dose of esketamine (0.2mg/kg) was administered intravenously after delivery of the severed umbilicus
Control group:The patient was injected intravenously with 0.9% sodium chloride injection of equal volume after delivery of the severed umbilicus

Sponsors

Chengdu Pidu District maternal and Child Health Care Hospital
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
20 Years to 40 Years

Inclusion criteria

Inclusion criteria: 1. American Society of Anesthesiologists (ASA) grade I, IIPatients undergoing cesarean section under combined spinal and epidural anesthesia; 2. Age over 20 years old, less than 40 years old; 3. Preoperative routine examination was normal; 4. Intravenous analgesia and transversal plane block were used after cesarean section.

Exclusion criteria

Exclusion criteria: 1. The patient was exposed to any of the drug ingredients in the study Sensitive or addicted; 2. Those who are unwilling to cooperate; 3. Patients with gestational hypertension, preeclampsia, eclampsia and other pregnancy complications or other underlying diseases; 4. can not accurately understand the visual analog scale (VAS), Pittsburgh Sleep Quality Index (PSQI), Edinburgh Postpartum Depression Scale (EPDS), insomnia Severity Index (ISI) and other contents; 5. Pittsburgh Sleep Quality Index (PSQI) greater than 5 before surgery; 6. The end time of the operation is from 24:00 to 6AM; 7. Participants considered unsuitable for clinical trials.

Design outcomes

Primary

MeasureTime frame
Sleep quality;Visual analog score;

Secondary

MeasureTime frame
Interleukin 18;C-reactive protein;Postoperative 24-hour salvage analgesia rate;Edinburgh Postnatal Depression Scale (EPDS) score;

Countries

China

Contacts

Public ContactLiu Shushu

Chengdu Pidu District maternal and Child Health Care Hospital

kaelin-shushu@163.com+86 138 8217 9240

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026