hypoxemia
Conditions
Interventions
control group:sufentanil or midazolam
esketamine group:esketamine
Sponsors
Beijing Friendship Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Patients18-90 years old scheduled for painless gastroscopy or GI endoscopy(part 2 only); 2. ASA I–III; 3. STOP-Bang >=3;
Exclusion criteria
Exclusion criteria: 1. without cooperation or consent; 2. Patients allergic to propofol and ketamine hydrochloride; 3. severe central nervous system disease and severe mental illness; 4. Long term use of sedative hypnotic drugs or sedative analgesics; 5. history of severe arrhythmia; hypertension without regular control; 6. acute pharyngitis, tonsillitis, or upper respiratory tract infection within a week; 7. pneumonia or SpO2 < 90%; 8. Untreated or undertreated patients with hyperthyroidism; 9. pregnancy or lactation; 10.participation in other clinical studies within the previous 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the incidence of hypoxemia;ED50 of propofol; | — |
Secondary
| Measure | Time frame |
|---|---|
| The incidence of severe hypoxemia;the duration of hypoxemia;minSpO2;the incidence of hypotension;he incidence of patients requiring emergency airway management; | — |
Countries
China
Contacts
Public ContactQi Xiuru
Department of Anesthesiology, Beijing Friendship Hospital, Capital Medical University
Outcome results
None listed