Helicobacter pylori infection
Conditions
Interventions
Experimental group:Venorosine: 20mg bid + Clarithromycin: 750mg bid for 14 days
control group:Venolazine: 20mg bid + Clarithromycin: 750mg bid for 10 days
Sponsors
Nansha Hospital, Guangzhou First People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Agreed to enroll patients; 2. Age 18-60 years old; 3. Hp infection was confirmed and Hp drug sensitive culture was performed through gastroscopy, indicating clarithromycin sensitive patients.
Exclusion criteria
Exclusion criteria: 1. Pregnant or lactating women, patients with recent childbearing plans 2. Persons with disabilities defined by law (blind, deaf, dumb, intellectual disability, mental disorder, physical disability); 3. Patients with previous allergy to experimental drugs (clarithromycin, vonoprazan); 4. Continuous use of adrenocortical steroids, nonsteroidal anti-inflammatory drugs, and anticoagulants; 5. Previous history of gastric surgery; 6. Use of PPI and P-CAB drugs in the past 2 weeks, use of antibiotics, bismuth and traditional Chinese medicine with antibacterial effect in the past 4 weeks; 7. Suspected or true history of alcohol and drug abuse. 8. Severe organic diseases of the digestive system, such as malignant tumors of the digestive tract, gastrointestinal bleeding, peptic ulcer with perforation/obstruction, intestinal obstruction, etc. 9. Severe systemic diseases, such as severe cardiovascular and cerebrovascular diseases, diabetes mellitus, chronic renal insufficiency, connective tissue diseases, nervous system diseases, etc. 10. There were other factors considered by the investigator to be unsuitable for inclusion or to preclude participation in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 14C breath test, 14C-UBT;The eradication rate of Hp in the two groups; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of adverse drug reactions; | — |
Countries
China
Contacts
Public ContactJia Li
Nansha Hospital, Guangzhou First People's Hospital
Outcome results
None listed