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Dynamic Monitoring of DNA Methylation for Predicting Lymphatic Metastasis in NSCLC (Stage IIA-IIIB): A Prospective, Observational Clinical Trial on Lung Cancer Recurrence and Metastasis

Dynamic Monitoring of DNA Methylation for Predicting Lymphatic Metastasis in NSCLC (Stage IIA-IIIB): A Prospective, Observational Clinical Trial on Lung Cancer Recurrence and Metastasis

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500099393
Enrollment
Unknown
Registered
2025-03-24
Start date
2025-03-24
Completion date
Unknown
Last updated
2025-03-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Non-small cell lung cancer

Interventions

Posioperative group:None

Sponsors

The first affiliated hospital, Zhejiang University, School of Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: Translation of Eligibility Criteria: (I) Participants of any gender, aged >= 18 years; (II) Patients with histologically or radiologically confirmed stage IIA-IIIB non-small cell lung cancer (NSCLC); (III) Patients who meet the criteria for and agree to undergo surgery; (IV) Able to comply with regular provision of 10 mL peripheral blood samples; (V) Willing to voluntarily participate in the study, sign an informed consent form, demonstrate good compliance, and actively cooperate with hospital-based clinical follow-up according to routine protocols.

Exclusion criteria

Exclusion criteria: (I) Female participants who are pregnant or breastfeeding; (II) Patients with a history of other malignancies within the past 5 years; (III) Participants who have received any blood transfusion within 30 days prior to enrollment; (IV) Patients who are unable to comprehend or obtain written informed consent.

Design outcomes

Primary

MeasureTime frame
DNA Methylation;Recurrence free survival time, RFS;3 year - progression free survival rate postoperatively, 3y-PFS;Progression Free Survival, PFS;

Countries

China

Contacts

Public ContactHu, Jian

The first affiliated hospital, Zhejiang University, School of Medicine

dr_hujian@zju.edu.cn+86 136 0570 8283

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026