Progressive Supranuclear Palsy
Conditions
Sponsors
Zhengzhou Central Hospital
Eligibility
Sex/Gender
All
Age
40 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Based on the current Movement Disorder Society (MDS) diagnostic criteria for progressive supranuclear palsy (PSP) (2017) and the Chinese clinical diagnostic criteria for PSP (2016), patients must meet the criteria for clinically confirmed PSP-Richardson syndrome (PSP-RS) or probable PSP-RS. 2.ge between 40 and 75 years. 3.Presence of PSP-RS clinical symptoms for at least 5 years. 4.Ability to walk independently for at least 5 steps. 5.Willingness to participate in the study and provide written informed consent. 6.Stable dosage of symptomatic treatment for PSP within 60 days prior to study initiation..
Exclusion criteria
Exclusion criteria: 1.Atypical variants of progressive supranuclear palsy (PSP). 2.PSP-Richardson syndrome (PSP-RS) patients unable to walk independently for at least 5 steps. 3.Severe cognitive impairment preventing compliance with study procedures. 4.Comorbid neurological or psychiatric disorders (e.g., schizophrenia, severe depression, bipolar disorder) or severe systemic diseases (e.g., acute coronary syndrome, acute heart failure, respiratory failure, severe hepatic or renal dysfunction, uncontrolled hyperthyroidism, poorly controlled rheumatic or autoimmune diseases). 5.Presence of metallic implants or pacemakers contraindicating cranial MRI examination. 6.Unstable general condition, vital signs, or uncontrolled seizures within one week prior to study initiation. 7.Pregnant, planning to conceive, or lactating women. 8.Unwillingness to comply with assessments and study procedures.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Progressive Supranuclear Palsy Rating Scale(PSPRS) score;Changes in hematological inflammatory markers; | — |
Secondary
| Measure | Time frame |
|---|---|
| Unified Parkinson's disease rating scale (UPDRS)-? score;Tinetti Balance and Gait Analysis score;Sematic Verbal Fluency score;Phonologic Verbal Fluency score;Schwab and England Activities of Daily Living Scale score;Clinical Global Impression score; Changes in brain lymphatic system imaging indices relative to baseline; | — |
Countries
China
Contacts
Public ContactYang Gaiqing
Zhengzhou Central Hospital
Outcome results
None listed